Conclusion: CBD is unlikely to be effective by itself for nausea and vomiting. The combination of THC and CBD does seem to be effective for nausea and vomiting.
Most studies investigating if CBD is beneficial at relieving nausea or vomiting, have used a combination of CBD and THC, rather than just CBD alone. A 2016 review found the combination to be either more effective or as effective as a placebo. 14
Conclusion: CBD may be beneficial at relieving pain but no high-quality human studies prove this.
9. Nausea and vomiting
Other trials of 300 mg of CBD in people with anxiety or depression showed that CBD appeared to preserve sleep architecture, meaning it was unlikely to have any negative effects on sleep quality. 10
We look at nine medical conditions where CBD may be, or, has already proven to be, beneficial.
Beneficial effects on anxiety after taking CBD were reported in an observational study where 21 patients out of 400 had anxiety. 8
CBD has also been investigated for use in other forms of treatment-resistant epilepsy, usually in addition to conventional epilepsy medications. Results varied, but several trials showed CBD significantly reduced seizure frequency by almost 44% in most people. 3
“Our top therapies attempt to break the association between reminders of the trauma and the fear response,” said Mallory Loflin, an assistant adjunct professor at the University of California, San Diego and the study’s principal investigator. “We think that CBD, at least in animal models, can help that process happen a lot faster.” While large clinical trials are underway, psychologists say there isn’t compelling evidence yet as to whether this is a viable treatment.
CBD is advertised as providing relief for anxiety, depression and post-traumatic stress disorder. It is also marketed to promote sleep. Part of CBD’s popularity is that it purports to be “nonpsychoactive,” and that consumers can reap health benefits from the plant without the high (or the midnight pizza munchies).
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Does CBD help anxiety and PTSD?
“It’s promising in a lot of different therapeutic avenues because it’s relatively safe,” said James MacKillop, co-director of McMaster University’s Michael G. DeGroote Center for Medicinal Cannabis Research in Hamilton, Ontario.
A few drops of CBD oil in a mocha or smoothie are not likely to do anything, researchers contend. Doctors say another force may also be at play in people feeling good: the placebo effect. That’s when someone believes a drug is working and symptoms seem to improve.
Up in the wee hours of the night, stuck watching videos of puppies? CBD may be promising as a sleep aid; one of the side effects of the Epidiolex trials for epilepsy was drowsiness, according to Mr. MacKillop, a co-author of a review on cannabinoids and sleep. “If you are looking for new treatments for sleep, that may be a clue,” he said.
The CBD industry is flourishing, conservatively projected to hit $16 billion in the United States by 2025. Already, the plant extract is being added to cheeseburgers, toothpicks and breath sprays. More than 60 percent of CBD users have taken it for anxiety, according to a survey of 5,000 people, conducted by the Brightfield Group, a cannabis market research firm. Chronic pain, insomnia and depression follow behind. Kim Kardashian West, for example, turned to the product when “freaking out” over the birth of her fourth baby. The professional golfer Bubba Watson drifts off to sleep with it. And Martha Stewart’s French bulldog partakes, too.
1. Pain So far, most of the evidence for CBD’s ability to reduce pain comes from animal-based research, including a study published in December 2017 in the journal Pain, which found that CBD applied on the skin of rats with osteoarthritis significantly reduced joint pain and inflammation. (10) Continued use of CBD also prevented further pain and nerve damage in those same joints.
During the two-month study, 72 adults in a psychiatric clinic were given CBD oil capsules once daily. Most received 25 milligrams (mg) of CBD with a few receiving doses as high as 175 mg. Within the first month, more than 79 percent of the patients reported feeling calmer, and they continued to feel calmer for the duration of the study. “We saw no evidence of a safety issue that would limit future studies,” the researchers added.
2. Anxiety While there haven’t been any large-scale clinical trials testing CBD oil as a treatment for generalized anxiety disorder , social anxiety , panic disorder , or phobias , a small study published in January 2019 in The Permanente Journal showed promising results. ( 2 )
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The trouble is there’s scant scientific evidence to support most of those claims, and there’s still a lot of uncertainty about CBD’s potential side effects and even its legality. “Cannabidiol is the No. 1 new treatment people are asking about,” says Susana Galle, PhD , a psychologist, clinical nutritionist, and certified naturopath in Washington, DC. “But although there’s tons of talk about it and lots of products out there, there’s still not much evidence.”
CBD-infused products fall into four basic categories, according to the book CBD: A Patient's Guide to Medicinal Cannabis — Healing Without the High : ( 3 )
In a nutshell, CBD interacts with the endocannabinoid system, a large messaging network in your body that plays a key role in regulating many physiological functions. In fact, cannabinoids are so essential to good health that your brain actually produces its own cannabinoids.
Although the science is scant, the British Journal of Pharmacology reported that some experts believe combining CBD with THC enhances CBD’s pharmacological benefits, a theory known as the “entourage effect.” ( 5 )