In June 2018, the U.S. Food and Drug Administration (FDA) approved Epidiolex, a CBD oral solution used for the treatment of certain rare forms of epilepsy in children under 2—Dravet syndrome and Lennox-Gastaut syndrome. Both are exceptionally rare genetic disorders causing lifelong catastrophic seizures that begin during the first year of life.
Medical marijuana is frequently prescribed to people with intractable (treatment-resistant) pain, including those with terminal cancer. There is some evidence that CBD contributes to this benefit.
Scientists believe that CBD reduces nerve pain by binding to glycine receptors in the brain that regulate the speed at which nerve signals pass between nerve cells.
CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.
CBD’s exact mechanism of action is unclear. Unlike THC, CBD has a relatively low affinity for cannabinoid receptors in the brain. These are the molecules to which THC binds to elicit its psychoactive effects.
CBD oil is an extract of Cannabis indica or Cannabis sativa—the same plants that, when dried, make marijuana. CBD oil is believed by some to treat pain, reduce anxiety, and stimulate appetite in the same way that marijuana does, but without its psychoactive effects. CBD has also shown promise in treating certain types of seizures.
According to the investigators, men provided 300 mg of CBD exhibited less anxiety than those given a placebo. Interestingly, those provided 100 mg or 600 mg of CBD oil did not.
CBD oil is a cannabis extract in oil form. There are many different methods for extracting compounds from cannabis. Many CBD products today are made using a supercritical CO2 extraction process to pull out all the cannabinoids and terpenes. The extracted compounds are then processed into the final CBD oil product. In some cases, producers will remove THC or other cannabinoids and terpenes, so that the final product contains only CBD.
Finally, it’s basically impossible to overdose on CBD, regardless of what form it’s in. Studies found that CBD had no adverse side effects at amounts up to 1200 milligrams daily, even when taken for several months.
How to take CBD oil
There are numerous ways to take CBD oil. For many users, this is one of the benefits of CBD oil. Some of the more common ways include dropping the CBD oil directly into your mouth or letting the CBD oil soak in under your tongue. Similarly, you can mix it into other foods and beverages to create your own CBD edibles. In some cases, depending on the oil and the reason the oil is being used, consumers may apply it topically. Finally, there are also some versions of CBD oil that have been mixed with a carrier oil, making it suitable for use in vape pens. If you are using one of these products, make sure that the oil you purchase is compatible with your vape pen and from a well-known, established producer.
A tincture is a concentrated plant extract made by soaking plant material in a potable alcohol solvent for several weeks. As it soaks, the solvent pulls out many of the chemical compounds in the plant material, creating a substance that is rich in the cannabinoids, terpenes, and other chemicals produced by the cannabis plant.
Read the label to understand more about the CBD in your tincture. Remember there are many different products available today, so pay attention to the type of CBD extract you’re purchasing. There are three primary types of extract: