Conclusion: CBD may be beneficial at relieving pain but no high-quality human studies prove this.
Several smalls studies have investigated using CBD to relieve symptoms of Parkinson’s Disease, with mostly encouraging results. For most studies, there were no differences across groups with regards to movement-related outcomes; however, groups treated with CBD 300 mg/day had a significantly improved well-being and quality of life as measured by the Parkinson’s Disease Questionnaire [PDQ-39]). 15
Animal studies have shown that CBD has a positive effect on serotonin levels in the brain, and serotonin. Low levels of serotonin are thought to play a key role in mood as well as pain. 11
Many other studies, both on animals and humans, have overwhelmingly concluded that CBD has immunosuppressive and anti-inflammatory properties which may make it a good choice for some autoimmune conditions or inflammation-related complaints. 16
Unfortunately, few human trials investigating the use of CBD as a single agent to relieve pain exist, with most trials using a combination of CBD and THC to relieve pain. Notably, Health Canada has approved a combination medication that contains both THC and CBD in a 1:1 ratio for the relief of central nerve-related pain in multiple sclerosis, and cancer pain that is unresponsive to optimized opioid therapy.
CBD tends to interact with a massive range of proteins in the central nervous system and body, including components of the endocannabinoid system (ECS), like the CB1 receptors in the central nervous system and brain, as well as the CB2 cannabinoid receptors found in the immune system and spleen.
CBD has also been seen to help reduce depression. CBD enhances both serotonergic and glutamate cortical signaling, which lack in people suffering from depression. Studies focused on using CBD oil to treat depression  have delivered promising results.
1. Can Relieve Pain
Acne is a common skin condition affecting more than 9% of the population  . Acne arises when dead skin cells, excess oil, or dirt accumulate clog the skin pores. When the skin pores are blocked, the bacteria that live in hair follicles, Propionibacterium acnes, or P. acnes, multiply, which leads to an inflammation known as acne.
Summary: Partly Effective – Some academic research proves that CBD can help combat addiction.
Additionally, a study published in Cellular Immunology in 2018  found that CBD may alter T-cells, which are part of the immune system, after spinal cord injury. It is believed that abnormal activities of T-cells are involved in Lupus as well.
Although the FDA has not approved using CBD to treat any of those conditions, there are signs CBD could be beneficial.
For Shannon Donnelly, her own experience with CBD is evidence enough. Since beginning a daily CBD regimen several years ago, she says her panic attacks are gone, as are other health problems, including depression. She currently takes 35 mg of CBD each morning and soaks in a tub of warm water laced with CBD bath salts each night.
The trouble is there’s scant scientific evidence to support most of those claims, and there’s still a lot of uncertainty about CBD’s potential side effects and even its legality. “Cannabidiol is the No. 1 new treatment people are asking about,” says Susana Galle, PhD , a psychologist, clinical nutritionist, and certified naturopath in Washington, DC. “But although there’s tons of talk about it and lots of products out there, there’s still not much evidence.”
Marijuana for Rheumatoid Arthritis Pain: Pros and Cons
Marijuana-derived CBD oil is extracted from high-THC cannabis plants, which can contain varying amounts of THC. (The ratio of CBD to THC is typically listed on the product label.) Any product with more than 0.3 percent THC is considered a controlled substance and can only be bought in a state where medical or recreational marijuana is legal. ( 4 )
And yet the buzz is so strong that to say CBD-infused products are selling like hotcakes would be an understatement. In 2018 alone, the Hemp Business Journal estimates, more than $500 million worth of CBD-infused oils, creams, patches, beer, coffee — even tampons and pet food — were sold in the United States, a number forecast to hit nearly $2 billion by 2022. ( 1 )
CBD-infused products fall into four basic categories, according to the book CBD: A Patient's Guide to Medicinal Cannabis — Healing Without the High : ( 3 )
According to a study published online in March 2018 in the International Journal of Molecular Sciences, the physiological functions affected by cannabinoids include: ( 6 )