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how long for cbd oil to leave system

If you consume CBD products in large amounts, and on a regular basis, it’s possible that this test – as well as the others – could detect it for longer.

In fact, recent research has shown that drug tests can’t tell the difference.

It’s also worth noting that because CBD products are not regulated by the FDA, it’s possible that you could be taking CBD that is mixed with other cannabinoids, which could increase detectability. Also, it’s worth noting that the more frequently you use cannabis products, the wider detection windows become.

How Long Does CBD Stay In Your Saliva?

Let’s take a closer look at the different ways you can take CBD and how your body processes it. Then we’ll walk through how long it will stay in different systems of your body.

Generally, THC is only detectable in your plasma for about five hours after you take it. However, THC metabolites and, therefore, CBD can be present for up to a week.

CBD, short for cannabidiol, has grown in popularity over the past couple of years, particularly as a supplement. However, because it contains trace amounts of THC, it’s still possible that it is detectable in drug tests or screenings.

There are many different factors to consider that influence how long CBD stays in your system as well as how it affects you. How long it lasts and is detectable is not the same for everyone. It can depend on:

In the intestines, CBD gets metabolized by the cytochrome P450 enzyme system, more specifically by the CYP3A4 isoenzyme, which accounts for nearly 70% of the total CYP450 in the intestine and 60% in the liver. The extensive metabolism by this enzyme in the intestines is what causes the poor bioavailability of many drugs [6].

If administered orally, CBD has low bioavailability of around 13-19%. Bioavailability of a drug (in this case CBD) is the amount of CBD that enters the circulation to produce an active effect [2].

According to several studies, CBD goes through the CYP450 enzyme system in the liver — the key pathway for drug metabolism [4]. This is where CBD is inactivated and prepared to be eliminated from the body via the kidneys.

How Does The Body Process CBD?

Inhaling CBD has shown to have rapid absorption rates because the lungs transfer CBD directly into the bloodstream. The compound reaches the blood within seconds, transferred by the network of capillaries.

According to an animal study published in Scientific Reports, if taken together with lipids CBD has a higher chance to follow the lymphatic transport. The study found that the CBD concentrations in the lymph were 250-fold higher than in plasma. This means that if taken with a high-fat meal, the oral administration of CBD is more effective.

Different methods of CBD administration produce different results. You may feel the effects of CBD quickly after inhalation. But, how long does CBD stick around after the effects wear off?

The very first pharmacological effect of CBD ever observed was related to drug interaction. CBD is both a substrate and an inhibitor of CYP450 enzymes, so it could interfere with the metabolism of other drugs.

Inhalation is also an effective delivery method for CBD due to its rapid absorption and the efficiency of the lungs at transferring CBD into the bloodstream. Whether you’re smoking a high-CBD strain or taking a draw from a CBD vape pen, the interaction with the body remains the same. When CBD is inhaled, the cannabinoids are sent directly to the lungs, where they are rapidly absorbed into the bloodstream and put into circulation.

Based on existing research, CBD may stay in your system anywhere from 24 hours to a few weeks. That timeframe can change depending on a variety of factors including metabolism, consumption method, frequency of use, and dosage.

Consumers who want to be extra-cautious and use CBD with no THC should shop for a broad-spectrum oil or a CBD product that contains pure CBD isolate. Broad-spectrum oil is refined to exclude THC, while CBD isolates contain no THC or other plant-based cannabinoids. To ensure that your CBD contains no THC, it’s important to source products from reputable manufacturers that provide a certificate of analysis from a third-party testing lab.

Inhalation

Oral ingestion is the most common method of CBD consumption. Administering a couple of drops of CBD oil directly into the mouth is certainly a convenient way to reap the potential benefits of this therapeutic cannabinoid. However, ingestion is not necessarily the most effective consumption method for those who want to feel the effects of CBD immediately.

Bottom line: Existing evidence suggests that CBD reaches peak blood concentration within three minutes after inhalation, meaning any effects should be felt shortly after use. The effects should then last anywhere from 45 minutes to a couple of hours.

Keep in mind that even hemp-derived CBD products are legally allowed to contain up to 0.3% THC. This could cause hesitation for some CBD-curious consumers who don’t want THC in their system or risk a false positive result on a drug test. However, the chances of failing a drug test from using hemp-extracted CBD oil are extremely slim. You would need to take an exorbitant dosage of full-spectrum CBD oil (estimates range from 1,000 to 2,000 milligrams per day) to risk a positive drug test result.

A 1991 study published in Pharmacology Biochemistry & Behavior examined the concentration of CBD in the blood after high doses daily. Over a six-week period, the research team administered a daily dose of 700 milligrams of CBD to 14 Huntington’s disease patients. One week after the dosing ceased, the CBD remaining in the blood was just 1.5 nanograms per milliliter and was “virtually undetectable” thereafter.