Some dosages that have been used in research studies for different conditions include:
It is also important to remember that CBD products are not regulated by the U.S. Food and Drug Administration (FDA). Some manufacturers make unproven claims about the uses and efficacy of their products. There is also concern about the quality and safety of the products themselves.
Mislabeling appears to be a fairly common problem with CBD products. In one study, 70% of the CBD products that were sold online contained significantly more of the psychoactive ingredient THC than the label indicated.
One 2020 review of studies found that participants showed improvements in anxiety levels after single doses of CBD ranging from 300 to 600 mg. Such results indicate that the CBD may hold promise as a treatment to alleviate symptoms of acute anxiety.
Some of the most common side effects that people experience when taking CBD include:
To find out—because there’s been relatively little rigorous research on CBD to date and I’m a skeptic by nature—I reached out to a doctor and a scientist for the 411. As I suspected, this isn’t a topic that has been studied in depth. Yet there is some reason to believe that certain CBD products may truly be more bioavailable when absorbed under the tongue than if taken through food or drink.
Sublingual delivery isn’t always a better option for all substances, points out Dr. Birdsall—some B vitamins, for instance, need to be “activated” by the liver in order to do their jobs—but for certain vitamins and medications, it can be a super effective delivery method.
Long story short: You may as well try holding your CBD oil or tincture under your tongue before swallowing it—you could find that you feel it working slightly faster. Anecdotally, says Dr. Birdsall, experts recommended that you hold it there for at least 60 seconds. (A word of warning: There will be drool.) Your other option is to try a product that’s specifically created to be absorbed sublingually, like Kin Slips, which are kind of like those breath-freshening films that dissolve in your mouth.
According to Timothy Birdsall, ND—a member of hemp education platform Prima’s medial advisory group—when you take certain substances sublingually, they can enter directly into your bloodstream, where they’re immediately shuttled to your tissues. Think of it as a shortcut to digestion, which is a longer process in which the substance needs to be ingested, broken down by the stomach, absorbed by the small intestine, and metabolized by the liver. “Not only do many compounds lose potential bioavailability during [the digestion] process, but the time to onset is delayed,” adds chemist Jessie Kater, senior vice president of manufacturing for Curaleaf and Curaleaf Hemp.
After all, if there’s one thing that can be said about the wild west of CBD, it’s that experimentation is key—whether you’re looking for your perfect dose or your perfect delivery method.