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And anandamide – the first discovered endocannabinoid neurotransmitter – is often called our ‘neurotransmitter of balance’. Why Should You Take CBD Daily? The reason to take CBD-rich hemp extracts every day is to supplement your own endocannabinoid system. CBD causes different effects on the various pieces of the endocannabinoid system – but one of the most important is its effects on the FAAH enzyme. The FAAH enzyme is responsible for degrading anandamide – and one of the actions of CBD is an inhibition of the FAAH enzyme. In preclinical research, when the FAAH enzyme is less active at degrading anandamide, the levels of anandamide rise. However, research is still ongoing into these effects. Importantly, the effects of CBD are not limited to the endocannabinoid system. As one of its key researchers, Dr. Vincenzo di Marzo points out, at the biochemical level, CBD is like a Swiss army knife. It seemingly has a tool for everything. Now, keep in mind, that almost all of this research on the biochemical bindings comes from animals, but in those models, they’ve found CBD to bind to a host of other cannabinoid receptors outside the endocannabinoid system: including three of the serotonin receptors;, one of the dopamine receptors; two of the opioid receptors; and a number of lesser known neurotransmitter receptors, such as adenosine, acetylcholine (‘fight vs flight’ response), glycine, GABA (your brain’s most common inhibitory neurotransmitter), and glutamate (your brain’s most common excitatory neurotransmitter). What is fascinating is that CBD also binds to the PPARα receptors on the surface of the nucleus. These control genetic transcription and the production of new proteins and messengers from your DNA. In one study of brain cells, the addition of CBD upregulated over 1,200 different genes and increased the cell’s ability to handle stress responses. 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