Side effects of CBD include nausea, fatigue and irritability. CBD can increase the level in your blood of the blood thinner coumadin, and it can raise levels of certain other medications in your blood by the exact same mechanism that grapefruit juice does. A significant safety concern with CBD is that it is primarily marketed and sold as a supplement, not a medication. Currently, the FDA does not regulate the safety and purity of dietary supplements. So, you cannot know for sure that the product you buy has active ingredients at the dose listed on the label. In addition, the product may contain other (unknown) elements. We also don’t know the most effective therapeutic dose of CBD for any particular medical condition.
CBD is commonly used to address anxiety, and for patients who suffer through the misery of insomnia, studies suggest that CBD may help with both falling asleep and staying asleep.
CBD is readily obtainable in most parts of the United States, though its exact legal status is in flux. All 50 states have laws legalizing CBD with varying degrees of restriction, and while the federal government still considers CBD in the same class as marijuana, it doesn’t habitually enforce against it. In December 2015, the FDA eased the regulatory requirements to allow researchers to conduct CBD trials. Currently, many people obtain CBD online without a medical cannabis license. The government’s position on CBD is confusing, and depends in part on whether the CBD comes from hemp or marijuana. The legality of CBD is expected to change, as there is currently bipartisan consensus in Congress to make the hemp crop legal which would, for all intents and purposes, make CBD difficult to prohibit.
Is CBD safe?
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CBD stands for cannabidiol. It is the second most prevalent of the active ingredients of cannabis (marijuana). While CBD is an essential component of medical marijuana, it is derived directly from the hemp plant, which is a cousin of the marijuana plant. While CBD is a component of marijuana (one of hundreds), by itself it does not cause a "high." According to a report from the World Health Organization, "In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health related problems associated with the use of pure CBD."
Some CBD manufacturers have come under government scrutiny for wild, indefensible claims, such that CBD is a cure-all for cancer, which it is not. We need more research but CBD may be prove to be an option for managing anxiety, insomnia, and chronic pain. Without sufficient high-quality evidence in human studies we can’t pinpoint effective doses, and because CBD is currently is mostly available as an unregulated supplement, it’s difficult to know exactly what you are getting. If you decide to try CBD, talk with your doctor — if for no other reason than to make sure it won’t affect other medications you are taking.
CBD may offer an option for treating different types of chronic pain. A study from the European Journal of Pain showed, using an animal model, CBD applied on the skin could help lower pain and inflammation due to arthritis. Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.
Let’s just say . it’s complicated. CBD products that are derived from hemp, with a low-to-zero percentage of THC (below 0.3%), are currently in a legal gray area in the US.
The myriad ways in which it works are not fully understood, but do not appear to center on the CB1 and CB2 receptors that THC acts on. Those receptors are part of the relatively newly-discovered endocannabinoid system, first described in 1992,  and increasingly found to be important to human health and well-being through maintaining homeostasis (balance) in various aspects of physiology.     CBD actually opposes the action of THC at the CB1 receptor (and certain other receptors as well), which can help counter THC’s (potential) worsening of cognition, memory, psychosis, and other effects.   Most notably, you won’t get “high” (at least in the conventional sense of the word) from CBD, due to its differential impact on CB1 compared to THC. 
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In December of 2018 though, the FDA stated that CBD cannot be marketed as a supplement without FDA approval, but in April of 2019, the FDA was taking public comments to formulate a revised position.  Currently, non-pharmaceutical CBD is technically only legal under very specific conditions, such as when the source hemp was produced in a manner consistent with the Farm Bill, and by a licensed grower. Complicating matters further: the DEA and individual states can have different legal perspectives on CBD. Clarification on CBD legality should come within the first half of 2019.
Anywho, back to CBD’s main effects. It appears to impact a variety of other receptors in the body, including an important receptor involved in pain and stress response, called TRPV1.    Other receptors that CBD impacts include GPR55, 5HTI-alpha, and adenosine A2A, which variously can help with inflammation, pain, anxiety, and even potentially cancer.    
Some people prefer to completely avoid THC when it comes to their hemp products, especially if they are concerned with taking a drug test. So if you’re shopping for an isolate CBD pill, the Medterra gel capsules are worth a try. These capsules, which have a 4.5-star rating, are made with 99.6% pure CBD derived from high-quality Kentucky hemp plants, and the products are completely devoid of THC. A bit of MCT oil is added to provide a smooth liquid suspension, and customers have the option to choose between two strengths: 25 or 50 milligrams per capsule.
Woven Earth uses a gentle lipid extraction process to translate the full power of organic hemp into a simple-to-dose vegan capsule. Each capsule contains 20 milligrams of CBD plus a range of natural plant qualities, including chlorophyll, flavonoids, and terpenes. Woven Earth Hemp Oil Capsules have long had a cult following among health professionals and are now available for anyone who wants to try CBD to combat the aches and stress that damage sleep.
It should also be said that a dropper of hemp oil has an earthy taste, which isn't to everyone's liking. A CBD tablet or softgel allows you to avoid this bitter flavor with one quick and easy swallow.
Best for Focus: Plant People Stay Sharp CBD Capsules
The Charlotte’s Web product line is known for its full spectrum CBD extracts, which come from American-grown hemp plants. This particular product is noteworthy for its array of naturally occurring phytocannabinoids, terpenes, flavonoids, and essential fatty acids. If you’re in the market for a strong CBD oil supplement, the 25 milligram capsules are a good option. If you want something less potent, Charlotte’s Web also offers other capsules with 15 milligrams of CBD in each (with a lower price per bottle).
Cornbread Hemp’s CBD oil capsules are regularly tested to be 100% free of pesticides, heavy metals, mycotoxins, and microbials. These full spectrum extracts also are a true “whole plant” product, meaning they contain a full range of cannabinoids, including a legal amount of THC.
The efficacy of CBD oil capsules and softgels vary from one product to the next, depending on the quality. Here are a few factors to keep in mind:
Regular dosing may allow you to empower your endocannabinoid system, or take advantage of the "entourage effect" with a full-spectrum CBD oil capsule. This is also why it's very important to research CBD brands. When buying a tablet for its potential health benefits, you want to avoid any harmful pesticides or solvents. A CBD supplement is meant to support wellness.