Inflammation is one of the main causes of hepatic encephalopathy. A study conducted on mice models of hepatic encephalopathy reported positive effects. The research team observed that applying CBD to mice could restore the neurological functions and cognitive performance in the mice. CBD also reduced the levels of ammonia in the blood, helping restore liver function and normalize the number of liver enzymes (7).
In this article, we’ll explain the context of the said study and provide evidence supporting the health benefits of regular doses of CBD for liver health.
One recent study has sparked concerns among CBD users when it comes to liver function. While the study did show that extremely large amounts of CBD can damage the liver, the news coverage that warned about the potential risk of taking CBD failed to put the study into context.
CBD Oil for Alcohol-Induced Liver Injury
The study has also garnered attention among CBD skeptics who have been trying to undermine the therapeutic potential of CBD looking for at least one serious side effect.
The ECS is responsible for regulating many of our homeostatic control processes. In other words, this network controls the balance of various systems and organs in the body, including the liver.
If you’re looking to improve liver function with CBD oil, you’re probably wondering how much CBD is enough to provide relief from pain and inflammation and to keep this organ healthy.
However, inflammation in the liver causes the endocannabinoid to be very active in this area. Unfortunately, an overactive endocannabinoid system plays a role in the development of fatty liver disease (3).
“Patients with hepatitis C who used cannabis had way more liver scarring than those who didn’t and more progression of their liver disease. Something in the cannabis could actually be increasing fatty liver disease,” Dr. Hardeep Singh, gastroenterologist at St. Joseph Hospital in Orange, California, told Healthline.
Lead study author Igor Koturbash, PhD, recently told the health site Nutra Ingredients USA that the risk of liver damage from CBD is a nasty side effect printed in black and white on GW Pharma’s Epidiolex packaging.
The photo of liver is on the man’s body against gray background, Liver disease or Hepatitis, Concept . [+] with body problem and male anatomy
Travers Stakes Picks And Preview On Biggest Day Of Racing At 2021 Saratoga Summer Meet
The latest study also finds that CBD has the potential for herbal and drug interactions. “CBD differentially regulated more than 50 genes, many of which were linked to oxidative stress responses, lipid metabolism pathways and drug metabolizing enzymes,” the study reads.
Liver toxicity is an adverse reaction to various substances. Alcohol, drugs and even some natural supplements can all take their toll on liver function – even in healthy individuals. But this is the first study of its kind indicating that CBD might be just as detrimental to the human liver as other chemicals.
“If you look at the Epidolex label,” he said, “it clearly states a warning for liver injury. It states you have to monitor the liver enzyme levels of the patients. In clinical trials, 5% to 20% of the patients developed elevated liver enzymes and some patients were withdrawn from the trials,” he added.
But come to find out, there has been evidence of CBD’s havoc wreaking ways on the liver for some time.
As determined by the studies done on Epidiolex®, CBD is metabolized by the liver. People with nonalcoholic steatohepatitis (NASH) are encouraged to limit over-the-counter (OTC) medications to avoid stressing the liver.
How does it impact the liver?
Cannabidiol oil is extracted from the hemp plant, which is in the same family as marijuana. Unlike THC in marijuana, CBD does not cause a “high” or chemical dependence. CBD that is extracted from the hemp plant is legal, but individual states have laws to regulate it.
How much CBD is too much?
Because CBD oil is not considered a drug, it can be a common additive in many products. This includes e-cigarettes (vape oil), lotions and various herbal supplements. It has also been shown to relieve symptoms of different disorders like epilepsy, anxiety and multiple sclerosis.
The few studies performed on how CBD affects the liver are not clear.
What is CBD oil?