2. Rudroff T, Sosnoff J. Cannabidiol to improve mobility in people with multiple sclerosis. Front Neurol. 2018;9:183.
Because of the way the endocannabinoid system works, the bioavailability of CBD is an important factor in how you will respond. Bioavailability is the amount of a substance that successfully makes it into the bloodstream and has an effect. Think about how some medications require you to take them with food or water, or on an empty stomach. Well, the amount of CBD that you actually absorb when taking a CBD product works the same way and will depend on:
8. Atalay S, Jarocka-Karpowicz I, Skrzydlewska E. Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants. 2020;9(1):21.
How does CBD help pain?
What about all those CBD products you’re seeing in line at the supermarket, the local health food store, and online? The market for CBD has basically exploded in the past few years but is completely unregulated. The CBD you buy may come from hemp or may not. It may contain the amount of CBD it claims or may not. It also may contain more THC than it claims. Welcome to the budding world (pun intended) of medicinal CBD.
A budtender – that’s what they call dispensary pharmacists – or your doctor can guide you, but here’s a quick overview.
Oral ingestions come in many forms such as:
Here’s a quick cheat sheet but note that efficacy of each is still up for debate.
8) SARINYAPINNGAM / Thinkstock
American Psychiatric Association: “Cannabidiol May Benefit Patients With Early Psychosis, Cannabis Misuse.”
Can It Ease Pain?
Frontiers in Pharmacology: “A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol.”
Journal of Experimental Medicine: “Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.”
So far, CBD doesn’t seem to cause serious ones. When it’s used to treat epilepsy or psychotic disorders, people reported tiredness, diarrhea, and changes in appetite. But CBD can affect how other medications work, so be sure to tell your doctor about everything you take, including vitamins and supplements.
When looking at flavored CBD oils, pay close attention to how the product is flavored. Natural and organic flavorings are safer.
Vitamin B12: According to the National Library of Medicine , “B12 may be an additional tool to consider for pain treatment”
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