The analogy is somewhat outdated today, but what used to happen to film that experienced breakdown or degradation? Haze? Blur? Spots? All of the above?
“Other possible applications of cannabinoids in ophthalmology could be explored,” the researchers wrote. “Age related macular degeneration (AMD) is the leading cause of blindness in the United Kingdom. Perhaps the potent antioxidant properties of the cannabinoids may be beneficial in AMD, offering a possible alternative to established antioxidant supplements.”
What is macular degeneration?
When the eye’s film—the cells within the macula—deteriorates, the brain fails to receive those images correctly. Known as macular degeneration, this regression can worsen and result in blurry vision. In severe cases, sufferers will lose their central vision, leaving only their peripheral vision and robbing them of the ability to read a book, drive a car, or even recognize the faces of loved ones.
A 1971 research study on glaucoma, published in the Journal of the American Medical Association (JAMA), found that many of the study’s participants experienced a 30% reduction in eye pressure after smoking marijuana. That type of success in a research trial led some to consider cannabis an alternative modality for treating the symptoms of glaucoma. It has also resulted in patients asking their doctors about using cannabis for other eye conditions like macular degeneration.
Conversely, wet macular degeneration occurs when abnormal blood vessels take shape under the retina. As they grow, those vessels begin to bleed and seep into the macula, warping and distorting the person’s vision.
MD is a deterioration of the central part of the retina, the back layer. That layer, called the “macula,” records images and sends them back to the brain. It’s in charge of focusing vision and helps humans read, recognize faces and many more important things. Without a functioning macula, the center of the field of vision is blurry, becoming worse over time.
CBD can also reduce cytokines, which are proteins that cause inflammation. Those proteins can cause retinal thickening and aid in the degeneration of the macular.
Macular degeneration (MD) is the highest cause of vision loss in the U.S., affecting over 10 million Americans.
At present, it is considered an incurable disease. But what is happening in the eye to cause MD?
Both THC and CBD have properties that some studies have shown can slow down or block the causes of macular degeneration, including VEGF. A 2004 study on brain tumours, for example, showed that THC can block VEGF pathways. This slows down the abnormal blood vessel growth in the eye brought on by VEGF.
VEGF, or Vascular Endothelial Growth Factor, can cause abnormal blood vessel growth around the eye. This can lead to macular degeneration.
It had also showed that cannabinoids inhibit the growth of VEGF. The goal of administering the strenuous injection of drugs directly into the eye for patients with macular degeneration is. Because these drugs can stop the progression of vascular endothelial growth factor (VEGF). However, it had also showed that cannabinoids do the same, with little or no severe side effects. A 2004 study by researchers at the Complutense University of Madrid, Spain in mice with gliomas (brain tumors), found that cannabinoids inhibited VEGF pathways, delaying tumor growth in mice. Two patients with glioma had the same effect.
researchers discovered that the area of the eyes has cannabinoid receptors
Currently, there is no cure for this disease. Available medications, such as Lucentis and Avastin, slow or prevent the increase in vision loss. Injections applied directly to the eye reduce vision loss.
Let’s look at how CBD can help for Macular Degeneration.
Although we need more research, correlations found between the healing powers of CBD, the functioning of age-related macular degeneration in an innovative Finnish study on glaucoma in 2002 prove its effectiveness. Published in the journal Pharmacology & Therapeutics, researchers discovered that the area of the eyes has cannabinoid receptors. This intricately complicated area of the body also forms part of the endocannabinoid system.
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