For this study, nine healthy men took either 600 mg of CBD or the same dose of a placebo. According to the researcher, those treated with CBD had lower blood pressure before and after exposure to stressful stimuli (including exercise or extreme cold).
In an analysis of 14 published studies (nine involving animals and five involving humans), scientists with the University of Montreal concluded that CBD showed promise in treating people with opioid, cocaine, or psychostimulant addiction.
Many of these interactions are mild and require no adjustment to treatment. Others may require a drug substitution or the separation of doses by several hours.
As CBD grows in popularity, so does the research on it but there are currently few clinical studies on the effects of CBD oil. As such, some of these claims are better supported by studies than others.
Among the few human trials evaluating CBD’s anxiolytic effects was one published in the Brazilian Journal of Psychiatry in 2019. For this study, 57 men were given either CBD oil or a placebo before a public-speaking event. Anxiety was evaluated using physiological measures (such as blood pressure, heart rate, etc.) and a relatively reliable test for mood states known as the Visual Analog Mood Scale (VAMS).
CBD oil should be avoided during pregnancy and breastfeeding. A 2018 study from the American Academy of Pediatrics warned women to avoid marijuana during pregnancy due to the potential risks to a baby’s development. Although it is unclear how CBD contributes, CBD is known to pass through the placental barrier.
CBD oil contains CBD mixed with an inert carrier oil, such as coconut oil or hemp seed oil. The bottled oil, called a tincture, is sold in various concentrations. There are also CBD capsules, CBD gummies, and under-the-tongue CBD sprays.
CBD is not psychoactive; it does not have a mind-altering effect.
The National Academies of Sciences (NAS) found significant evidence that cannabis was an effective treatment for long-term (chronic) pain. However, much of the research was done outside of the U.S. And the forms of cannabis studied in the U.S. were not the same as those commonly used.
CBD vs. THC
CBD may also increase the risk of side effects of certain medicines if used with them. Speak to your doctor or pharmacist before taking CBD with any other medication.
Applications of transdermal cannabidiol were studied in people with temporomandibular (joint of the jaw) disorders (TMD) that caused myofascial (coverings of muscle) pain. Those studied had less muscle activity and pain after applying the topical CBD for 2 weeks.
Studies of CBD are ongoing, but some benefits have been found.