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State Legalization of Medical Marijuana

A Word About Hemp

See also, a 2019 blog on PainDr (managed by Jeff Fudin, PharmD, PPM editor-at-large) on hemp use and drug screenings).

Dr. Bearman said he also prescribes dronabinol, the man-made or synthetic THC, for some patients. “It doesn’t work as well as cannabis, it’s more expensive than cannabis, and it has more side effects than cannabis. Nevertheless, there are some good reasons for prescribing it,” he noted. Specifically, because dronabinol is regulated by the FDA and must meet purity and manufacturing standards, he knows exactly how much THC a patient is getting.

Cannabis is Complex: CBD Versus THC

Two of the cannabinoids found in cannabis, Δ 9 -tetrahydrocannabinol (THC) and cannabidiol (CBD), along with other cannabinoids, terpenes, and flavonoid compounds, are thought to exhibit synergistic effects that promote pain relief. 5 THC is the most psychoactive cannabinoid found in cannabis and is primarily responsible for the “high” associated with marijuana. It can also reduce nausea and increase appetite. CBD does not provide the euphoria associated with THC and is associated with reduced pain and inflammation. 6

C. sativa is associated with higher levels of THC while C. indica is associated with higher levels of CBD. The science is more complicated. A 2015 study 11 of genetic structures of marijuana and hemp suggests that “C. sativa and C. indica may represent distinguishable pools of genetic diversity but that breeding has resulted in considerable admixture between the two.” Researchers also found that hemp has more in common genetically with C. indica than with C. sativa. Differences in THC production held true.

The White is a prolific hybrid best known for its thick coat of white crystal resin. Leafly reviewers praise The White for its pain-relieving qualities, and perhaps the reason for this is its rich terpene profile that typically boasts high levels of caryophyllene alongside a hearty cannabinoid content.

Cannabinoid profile: Balanced THC/CBD

Cannabinoid profile: THC-dominant

Blueberry Headband

Primary terpenes: Caryophyllene, limonene, myrcene

This guide is informed both by user-submitted strain reviews on Leafly and chemical profile data.

Cannabinoid profile: CBD-dominant

Primary terpenes: Caryophyllene, myrcene, limonene

The good news is that cannabis has the potential to treat all three types of pain, in different ways.

A versatile strain that’s equally appropriate for daytime or nighttime use, Shurman tends to quiet your nerves and anxiety while boosting motivation and focus.

White Widow

As we’ve written before, though, those cannabinoids aren’t the only thing fighting inflammation and pain. Many terpenes elicit analgesic (pain-fighting) and anti-inflammatory responses in the body; now it appears that some members of the largely under-researched class of compounds called flavonoids have powerful anti-inflammatory effects as well. Two of the best strains for nociceptive pain include:

This high-THC strain has an optimal amount of CBD as a buffer (1-4%) to mitigate some of its effects. Fans love its daytime or nighttime versatility and ability to tame pain.

Touted as being effective in treating inflammation, muscle pain, muscle spasms, and stress. Not only is it hugely medicinal, with its earthy, woody, and sweet flavors, it’s delicious, happy and uplifting