Conclusion: CBD is unlikely to be effective by itself for nausea and vomiting. The combination of THC and CBD does seem to be effective for nausea and vomiting.
Animal studies have shown that CBD has a positive effect on serotonin levels in the brain, and serotonin. Low levels of serotonin are thought to play a key role in mood as well as pain. 11
Conclusion: CBD may be beneficial at relieving pain but no high-quality human studies prove this.
9. Nausea and vomiting
Most studies investigating if CBD is beneficial at relieving nausea or vomiting, have used a combination of CBD and THC, rather than just CBD alone. A 2016 review found the combination to be either more effective or as effective as a placebo. 14
Conclusion: CBD does not appear to interfere with sleep and may help people sleep better.
We look at nine medical conditions where CBD may be, or, has already proven to be, beneficial.
Animal studies showed that topical CBD applications relieve pain and inflammation associated with arthritis with few side effects. The topical application of CBD is beneficial because CBD is poorly absorbed when taken by mouth and can cause gastrointestinal side effects. 6
Research into some of these claims is ongoing, and there is still a lot about CBD that we don’t know but researchers are trying to find out.
CBD is an abbreviation for cannabinoid. Cannabinoid is a natural substance found in cannabis, also known as marijuana, and also in hemp plants. Today, you can find CBD oil in capsules, oil bases for vaporizers, tinctures, food items, and beauty products such as bath bombs or lotions.
Unlike its cousin THC, CBD is not intoxicating or psychoactive. Proponents of CBD oil claim that it can be used to treat conditions such as chronic pain, inflammation, migraines, epilepsy, autoimmune diseases, depression, and anxiety.
CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.
Outside of these two disorders, CBD’s effectiveness in treating seizures is uncertain. Even with Epidiolex, it is uncertain whether the anti-seizure effects can be attributed to CBD or some other factor.
There is currently no known “correct” dose of CBD oil. Depending on individual needs and what is being treated, the daily dose may range between 5 and 25 mg.
Among the few human trials evaluating CBD’s anxiolytic effects was one published in the Brazilian Journal of Psychiatry in 2019. For this study, 57 men were given either CBD oil or a placebo before a public-speaking event. Anxiety was evaluated using physiological measures (such as blood pressure, heart rate, etc.) and a relatively reliable test for mood states known as the Visual Analog Mood Scale (VAMS).
Many of these interactions are mild and require no adjustment to treatment. Others may require a drug substitution or the separation of doses by several hours.
CBD’s exact mechanism of action is unclear. Unlike THC, CBD has a relatively low affinity for cannabinoid receptors in the brain. These are the molecules to which THC binds to elicit its psychoactive effects.
There is some evidence that CBD interacts with seizure medications such as Onfi (clobazam) and boosts their concentration in the blood. Further research is needed.